@Article{	  Rogala2017,
  author	= {Maja Rogala and Monika E. Danielewska and Agnieszka Antończyk and Zdzisław Kiełbowicz and Marta E. Rogowska and Marta Kozuń and Jerzy Detyna and D. Robert
		  Iskander},
  title		= {In-vivo corneal pulsation in relation to in-vivo intraocular pressure and corneal biomechanics assessed in-vitro. {A}n animal pilot study},
  journal	= {Experimental Eye Research},
  year		= {2017},
  volume	= {162},
  number	= {Supplement C},
  pages		= {27 -- 36},
  issn		= {0014-4835},
  abstract	= {The aim was to ascertain whether the characteristics of the corneal pulse (CP) measured in-vivo in a rabbit eye change after short-term artificial increase of
		  intraocular pressure (IOP) and whether they correlate with corneal biomechanics assessed in-vitro. Eight New Zealand white rabbits were included in this study and
		  were anesthetized. In-vivo experiments included simultaneous measurements of the CP signal, registered with a non-contact method, IOP, intra-arterial blood
		  pressure, and blood pulse (BPL), at the baseline and short-term elevated IOP. Afterwards, thickness of post-mortem corneas was determined and then uniaxial
		  tensile tests were conducted leading to estimates of their Young's modulus (E). At the baseline IOP, backward stepwise regression analyses were performed in which
		  successively the ocular biomechanical, biometric and cardiovascular predictors were separately taken into account. Results of the analysis revealed that the 3rd
		  CP harmonic can be statistically significantly predicted by E and central corneal thickness (Models: R2 = 0.662, p < 0.005 and R2 = 0.832, p < 0.001 for the
		  signal amplitude and power, respectively). The 1st CP harmonic can be statistically significantly predicted by the amplitude and power of the 1st BPL harmonic
		  (Models: R2 = 0.534, p = 0.015 and R2 = 0.509, p < 0.018, respectively). For elevated IOP, non-parametric analysis indicated significant differences for the power
		  of the 1st CP harmonic (Kruskal–Wallis test; p = 0.031) and for the mean, systolic and diastolic blood pressures (p = 0.025, p = 0.019, p = 0.033,
		  respectively). In conclusion, for the first time, the association between parameters of the CP signal in-vivo and corneal biomechanics in-vitro was confirmed. In
		  particular, spectral analysis revealed that higher amplitude and power of the 3rd CP harmonic indicates higher corneal stiffness, while the 1st CP harmonic
		  correlates positively with the corresponding harmonic of the BPL signal.},
  doi		= {https://doi.org/10.1016/j.exer.2017.07.003},
  keywords	= {Corneal biomechanics},
  url		= {http://www.sciencedirect.com/science/article/pii/S0014483516304043}
}